For a relaxing, local experience in the heart of Colorado’s wine country, discover these bed and breakfasts in Grand Junction and Palisade. Surrounded by the scenic landscape of the Bookcliff Mountains of the Grand Mesa and the Colorado National Monument, a trip to the Western Slope is not only one for wine lovers but for outdoor enthusiasts as well.
From quaint farmhouses to vineyard stays, discover your home away from home with these cozy bed and breakfasts in Grand Junction and Palisade.
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Here are among the best B&Bs in Grand Junction and Palisade, CO, in no particular order:
Castle Creek Manor — Grand Junction

For luxury without the price tag, check in to the Castle Creek Manor. A locally run inn, the Castle Creek Manor offers luxurious details and furnishings within a relaxed and welcoming environment.
Guests love their full country breakfast using locally sourced ingredients and are often served with mimosas for a delicious brunch. Enjoy your breakfast inside in their dining area or take it outside to enjoy on the large deck overlooking the creek.
Located in Grand Valley, in the heart of Grand Junction, the inn provides a convenient walking location to several restaurants and shops, plus they provide shuttle service to the airport and train station nearby.

Amenities:
- Free full breakfast
- Hot tub
- Outdoor deck with scenic views
- Common area
- Airport shuttle
- Ski storage
- Parking
- Free Wi-Fi
Choose from five distinct rooms, each with its own charm and character that highlight what the Grand Valley is known for. From the romantic Lavender Room, which represents the lavender fields that dot the valley, to the Two Rivers Room, which speaks to the joining of the Colorado River and the Gunnison River.
All rooms feature an external private entrance, a fireplace, a King-size bed, an ensuite bathroom with a two-person soaking tub, refrigerator, T.V., and other modern amenities.
- 638 Horizon Dr, Grand Junction, CO 81506 | 970-241-9105
- Check prices, availability or book Castle Creek Manor
The Chateau at Two Rivers Winery — Grand Junction

Inspired by the stylish details of a French Country Chateau, the Chateau at Two Rivers Winery offers elegant accommodations on a local vineyard and winery. Enjoy the full experience of wine country in Grand Junction with a stay in one of their 10 guest rooms in the Chateau that offer beautiful views of the vineyard and surrounding scenery. The Chateau also features event space for weddings and reunions.
The family-operated winery has been in operation since 1999 and pours six varieties including, a chardonnay, merlot, cabernet sauvignon, Riesling, Syrah, and a port. The tasting room is open daily, along with a daily breakfast served from 7:30 to 9:30 a.m. Enjoy the beauty of the Bookcliff Mountains and the Grand Mesa while you sip on your favorite glass of wine.

Amenities:
- Daily breakfast
- Updated rooms
- Scenic views
- On-site winery and vineyard
- Pet-friendly
- Free Wi-Fi
Guests can choose from 10 distinct guest rooms in the Chateau, with each offering modern amenities such as a T.V. and free Wi-Fi. The Champagne Suite is their largest, with a King-size bed, a fireplace, and a large garden tub in the private bathroom. The large and medium suites offer either a King-size bed or two Queen-size beds, a private bath, and a sitting area.
- 2087 Broadway, Grand Junction, CO 81507 | 970-255-1471
- Check prices, availability or book The Chateau at Two Rivers Winery
Dreamcatcher Bed and Breakfast — Palisade

Located just outside of Palisade, the Dreamcatcher Bed and Breakfast is a quaint house that overlooks the valley with stunning views of the mesa cliffs and Mt. Garfield. Built-in the 1920s, the home features unique details including, the copper railing, wooden ceilings, and cozy alcoves in the Colorado Room.
A unique aspect of the property is the treehouse located out front. Struck down by a storm, the 100+-year-old willow tree was soon converted into a treehouse or more like a tiny shed inside of a large tree stump. It’s just the kind of charm and character you will find at this homey bed and breakfast.
Amenities:
- Daily breakfast
- Sun deck
- Scenic views
- Common area
- Free parking
- Free Wi-Fi
Guests can choose from four different rooms, the Colorado Room, the Evening Star Room, the Knotty Pine Room, and the Mesa Room. Each feature a private bathroom, a T.V., a mini-fridge, plus a Jacuzzi tub in the Knotty Pine and Evening Star Suite.
For a romantic getaway to wine country, stay in the Evening Star Room, complete with a King-size bed with a lace canopy and an observatory for watching sunsets and the night sky.
- 3694 F Rd, Palisade, CO 81526 | 970-464-9900
- Check prices, availability or book Dreamcatcher Bed and Breakfast
Cherokee Vineyard Bed & Breakfast — Palisade

Enjoy the full wine country experience in the Grand Valley with a stay at the Cherokee Vineyard Bed & Breakfast. Located in Palisade, the working vineyard offers three guest rooms for those who want to stay and experience a working vineyard. Watch the sunrise over the Grand Mesa while enjoying your morning breakfast, explore the vineyard grounds, and enjoy a glass, or two, of wine.
The vineyard has been in operation since 2005 and grows cabernet franc, viognier, tempranillo, and other grapes for a nice blend of varietals.
Amenities:
- Located on a vineyard
- Daily breakfast
- Balcony with hot tub
- Scenic views
- Free Wi-Fi
Guests can choose from three distinct rooms including, the Breedlove Suite, Farmer’s Room, and Walter’s Study. The Breedlove suite is the largest space with a master suite and scenic views. The other two rooms are smaller, with the Farmer’s Room equipped with a Queen-size bed and Walter’s Study featuring a single-day bed – perfect for the single traveler.
- 3406 C 1/2 Rd, Palisade, CO 81526 | 970-363-4015
- Check prices, availability or book Cherokee Vineyard Bed & Breakfast
Vistas and Vineyards Bed & Breakfast

Located in the nearby town of Palisade, along the Fruit and Wine Byway, the Vistas and Vineyards BnB is in the heart of the wine country. Located within walking distance of three tasting rooms and nine tasting rooms within four miles, the inn provides convenient access to vineyard highlights within the Grand Valley.
Guests enjoy the beautiful views of Mt. Garfield at the front and the Grand Mesa from the back deck or relax indoors in the comfortable and relaxing common area, complete with a warming fireplace.

Amenities:
- Adults-only
- Near wineries
- Daily fresh breakfast
- Cruiser bikes available
- Back deck with scenic views
- Pet-friendly
- Free Wi-Fi
There are four themed rooms to choose from, each reminiscent of the owner’s favorite places: Southwest Sunsets, Nature Room, North by Northwest Suite, and the Ocean Suite. Each room is equipped with an ensuite bathroom, either a King or Queen-size bed, and modern amenities such as a mini-fridge and free Wi-Fi.
The North by Northwest Suite and Ocean Suite are larger and offer a sitting area and spa tub.
- 3587 G Rd, Palisade, CO 81526 | 970-464-7478
- Check prices, availability or book Vistas & Vineyards BnB
Get a taste of Colorado’s wine country and the local’s life with a stay in these bed and breakfasts in Grand Junction and Palisade. Have a relaxing time on the Western Slope!